Journal article
Diet quality, dietary inflammatory index and body mass index as predictors of response to adjunctive N-acetylcysteine and mitochondrial agents in adults with bipolar disorder: A sub-study of a randomised placebo-controlled trial
MM Ashton, OM Dean, W Marx, M Mohebbi, M Berk, GS Malhi, CH Ng, SM Cotton, S Dodd, J Sarris, M Hopwood, K Faye-Chauhan, Y Kim, SR Dash, FN Jacka, N Shivappa, JR Hebert, A Turner
Australian and New Zealand Journal of Psychiatry | SAGE PUBLICATIONS LTD | Published : 2020
Abstract
Aims: We aimed to explore the relationships between diet quality, dietary inflammatory potential or body mass index and outcomes of a clinical trial of nutraceutical treatment for bipolar depression. Methods: This is a sub-study of a randomised controlled trial of participants with bipolar depression who provided dietary intake data (n = 133). Participants received 16 weeks adjunctive treatment of either placebo or N-acetylcysteine-alone or a combination of mitochondrial-enhancing nutraceuticals including N-acetylcysteine (combination treatment). Participants were followed up 4 weeks post-treatment discontinuation (Week 20). Diet was assessed by the Cancer Council Victoria Dietary Questionna..
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Awarded by National Institutes of Health
Funding Acknowledgements
The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: The study has been funded by CRC for Mental Health, the Stanley Medical Research Institute and an NHMRC Project Grant (APP1026307). M.M.A. is supported by Deakin University, Australasian Society for Bipolar and Depressive Disorders (ASBDD)/Lundbeck and Australian Rotary Health/Ian Parker Bipolar Research Fund. O.M.D. is supported by a NHMRC R.D. Wright Biomedical Research Fellowship (APP1145634). M.B. is supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (APP1059660 and APP1156072). F.N.J. is supported by an NHMRC Career Development Fellowship (2) (APP1108125). S.C. is supported by a NHMRC Senior Research Fellowship (APP1136344). J. S. is funded by an NHMRC Clinical Research Fellowship (APP1125000). The sponsors and funding bodies have played no role in collection, analysis, interpretation of results or writing of the manuscript.