Genioglossus muscle responses to resistive loads in severe OSA patients and healthy control subjects
Warren R Ruehland, Peter D Rochford, Robert J Pierce, John Trinder, Amy S Jordan, Jennifer M Cori, Fergal J O'Donoghue
Journal of Applied Physiology | AMER PHYSIOLOGICAL SOC | Published : 2019
This study aimed to determine whether there is impairment of genioglossus neuromuscular responses to small negative pressure respiratory stimuli, close to the conscious detection threshold, in obstructive sleep apnea (OSA). We compared genioglossus electromyogram (EMGgg) responses to midinspiratory resistive loads of varying intensity (≈1.2-6.2 cmH2O·L-1·s), delivered via a nasal mask, between 16 severe OSA and 17 control participants while the subjects were awake and in a seated upright position. We examined the relationship between stimulus intensity and peak EMGgg amplitude in a 200-ms poststimulus window and hypothesized that OSA patients would have an increased activation threshold and ..View full abstract
Awarded by National Health and Medical Research Council of Australia
This study was supported by research grants from the National Health and Medical Research Council of Australia (Grant 430302), the Austin Medical Research Foundation, the Jack Brockhoff Foundation, and the Institute for Breathing and Sleep.