Journal article

Disturbed Cerebellar Growth Trajectories in Adolescents Who Initiate Alcohol Drinking

Edith Sullivan, Ty Brumback, Susan F Tapert, Sandra A Brown, Fiona C Baker, Ian M Colrain, Devin Prouty, Michael D De Bellis, Duncan B Clark, Bonnie J Nagel, Kilian M Pohl, Adolf Pfefferbaum

Biological Psychiatry | ELSEVIER SCIENCE INC | Published : 2020

Abstract

BACKGROUND: The cerebellum is a target of alcoholism-related brain damage in adults, yet no study has prospectively tracked deviations from normal cerebellar growth trajectories in adolescents before and after initiating drinking. METHODS: Magnetic resonance imaging tracked developmental volume trajectories of 10 cerebellar lobule and vermis tissue constituents in 548 no/low drinking youths age 12 to 21 years at induction into this 5-site, NCANDA (National Consortium on Alcohol and NeuroDevelopment in Adolescence) study. Over the 3- to 4-year longitudinal examination yielding 2043 magnetic resonance imaging scans, 328 youths remained no/low drinkers, whereas 220 initiated substantial drinkin..

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Grants

Awarded by National Institute on Drug Abuse


Awarded by National Institute of Mental Health


Awarded by National Institute of Child Health and Human Development (NCANDA)


Awarded by National Institute on Alcohol Abuse and Alcoholism


Funding Acknowledgements

This work was supported by the National Institute on Alcohol Abuse and Alcoholism with co-funding from the National Institute on Drug Abuse, National Institute of Mental Health, and National Institute of Child Health and Human Development (NCANDA Grant Nos. AA021697 [principal investigators, AP and KMP], AA021695 [principal investigators, SFT and SAB], AA021692 [principal investigator, SFT], AA021696 [principal investigators, IMC and FCB], AA021681 [principal investigator, MDDB], AA021690 [principal investigator, DBC], AA021691 [principal investigator, BJN]) and National Institute on Alcohol Abuse and Alcoholism (Grant No. R37 AA010723 [principal investigator, EVS]).