Journal article

ATP synthase inhibitory factor 1 (IF1), a novel myokine, regulates glucose metabolism by AMPK and Akt dual pathways

Hye Jeong Lee, Jiyoung Moon, InHyeok Chung, Ji Hyung Chung, Chan Park, Jung Ok Lee, Jeong Ah Han, Min Ju Kang, Eun Hye Yoo, So-Young Kwak, Garam Jo, Wonil Park, Jonghoon Park, Kyoung Min Kim, Soo Lim, Kevin RW Ngoei, Naomi XY Ling, Jonathan S Oakhill, Sandra Galic, Lisa Murray-Segal Show all

The FASEB Journal | WILEY | Published : 2019

Abstract

ATPase inhibitory factor 1 (IF1) is an ATP synthase-interacting protein that suppresses the hydrolysis activity of ATP synthase. In this study, we observed that the expression of IF1 was up-regulated in response to electrical pulse stimulation of skeletal muscle cells and in exercized mice and healthy men. IF1 stimulates glucose uptake via AMPK in skeletal muscle cells and primary cultured myoblasts. Reactive oxygen species and Rac family small GTPase 1 (Rac1) function in the upstream and downstream of AMPK, respectively, in IF1-mediated glucose uptake. In diabetic animal models, the administration of recombinant IF1 improved glucose tolerance and down-regulated blood glucose level. In addit..

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Grants

Awarded by National Research Foundation of Korea (NRF) - Ministry of Education


Awarded by Korea Research Fellowship (KRF) Grant


Funding Acknowledgements

This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2016R1610722). This work was also supported by Korea Research Fellowship (KRF) Grant 2018R1E1A2A02085743. The authors declare no conflicts of interest.