Journal article

Multicentre randomised double-blind placebo controlled trial of combination vancomycin and cefazolin surgical antibiotic prophylaxis: the Australian surgical antibiotic prophylaxis (ASAP) trial

Trisha Peel, Sarah Astbury, Allen C Cheng, David Paterson, Kirsty Buising, Tim Spelman, Tran-Duy An, Richard S de Steiger, Peter Choong, Allen Cheng, David Paterson, Kirsty Buising, Michelle Dowsey, Ross Crawford, Tim Spelman, Philip Clarke, Ben Howden, Peter Rehfisch, Robert Molnar, Sam Adie Show all

BMJ OPEN | BMJ PUBLISHING GROUP | Published : 2019

Abstract

INTRODUCTION: Resistant Gram-positive organisms, such as methicillin-resistant staphylococci, account for a significant proportion of infections following joint replacement surgery. Current surgical antimicrobial prophylaxis guidelines recommend the use of first-generation or second-generation cephalosporin antibiotics, such as cefazolin. Cefazolin, however, does not prevent infections due to these resistant organisms; therefore, new prevention strategies need to be examined. One proposed strategy is to combine a glycopeptide antibiotic with cefazolin for prophylaxis. The clinical benefit and cost-effectiveness of this combination therapy compared with usual therapy, however, have not been e..

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