Journal article

Dynamics of switching, adherence, and persistence of dipeptidyl peptidase-4 inhibitors use: A nationwide cohort study

Richard Ofori-Asenso, Jenni Ilomaki, Ken Lee Chin, Mohsen Mazidi, Ella Zomer, J Simon Bell, Dianna J Magliano, Danny Liew

Diabetes Research and Clinical Practice | ELSEVIER IRELAND LTD | Published : 2019


AIMS: To characterise the patterns of switching, adherence, and persistence among adults aged ≥18 years with diabetes prescribed dipeptidyl peptidase-4 inhibitors (DPP-4is) in Australia. METHODS: The analysis included 15,915 adults newly prescribed DPP-4is (sitagliptin = 9576; vildagliptin = 1130; saxagliptin = 1126; linagliptin = 3560; and alogliptin = 523). Multivariable logistic regression model was used to compare the non-adherence (proportion of days covered [PDC] <0.80) rates whereas Cox proportional hazards regression models were used to compare switching and non-persistence (≥90-day gap) among different DPP4-is over 12-months. RESULTS: Overall, 36.0% (5722/15,915) of DPP-4i users wer..

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