Journal article

The prebiotic effect of CPP-ACP sugar-free chewing gum

James R Fernando, Catherine A Butler, Geoffrey G Adams, Helen L Mitchell, Stuart G Dashper, Karen Escobar, Brigitte Hoffmann, Peiyan Shen, Glenn D Walker, Yi Yuan, Coralie Reynolds, Eric C Reynolds

Journal of Dentistry | ELSEVIER SCI LTD | Published : 2019


OBJECTIVES: To determine if chewing gum containing casein phosphopeptide stabilised amorphous calcium phosphate (CPP-ACP) promoted an increase in the abundance ofStreptococcus sanguinis and other species associated with dental health in supragingival plaque in a clinical study. MATERIALS AND METHODS: Nineteen participants were recruited for a three-leg cross-over, randomised, controlled clinical trial. Participants chewed a sugar-free gum with or without CPP-ACP six times daily for 20 min over two weeks. The study also involved no gum chewing (no gum) for the same two week period. Participants were randomly assigned to one of the test gums or no gum for each intervention period. Participants..

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