The prebiotic effect of CPP-ACP sugar-free chewing gum
James R Fernando, Catherine A Butler, Geoffrey G Adams, Helen L Mitchell, Stuart G Dashper, Karen Escobar, Brigitte Hoffmann, Peiyan Shen, Glenn D Walker, Yi Yuan, Coralie Reynolds, Eric C Reynolds
JOURNAL OF DENTISTRY | ELSEVIER SCI LTD | Published : 2019
OBJECTIVES: To determine if chewing gum containing casein phosphopeptide stabilised amorphous calcium phosphate (CPP-ACP) promoted an increase in the abundance of Streptococcus sanguinis and other species associated with dental health in supragingival plaque in a clinical study. MATERIALS AND METHODS: Nineteen participants were recruited for a three-leg cross-over, randomised, controlled clinical trial. Participants chewed a sugar-free gum with or without CPP-ACP six times daily for 20 min over two weeks. The study also involved no gum chewing (no gum) for the same two week period. Participants were randomly assigned to one of the test gums or no gum for each intervention period. Participant..View full abstract
Awarded by Australian Government Department of Industry, Innovation and Science Grant
This study was funded by the Australian Government Department of Industry, Innovation and Science Grant ID 20080108. The funding organisation had no role in the study design, implementation, analysis or interpretation of the data.