Journal article
Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults
Federico d'Oleire Uquillas, Heidi IL Jacobs, Aaron P Schultz, Bernard J Hanseeuw, Rachel F Buckley, Jorge Sepulcre, Alvaro Pascual-Leone, Nancy J Donovan, Keith A Johnson, Reisa A Sperling, Patrizia Vannini
Cerebral Cortex | OXFORD UNIV PRESS INC | Published : 2020
Abstract
Judgments of learning (JOL) pertain to introspective metamemory processes evaluating how well information is learned. Using a functional magnetic resonance imaging (fMRI) task, we investigated the neural substrates of JOL predictions in a group of 105 cognitively unimpaired older adults from the Harvard Aging Brain Study. Associations of JOL performance and its neural correlates with amyloid-β (Aβ) and tau pathology, two proteinopathies associated with Alzheimer's disease (AD) and aging, were also examined. We found that trials judged as learned well relative to trials judged as learned less well (high JOL > low JOL) engaged the ventromedial prefrontal cortex and precuneus, among other midli..
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Awarded by National Institutes of Health
Awarded by Alzheimer's Association
Awarded by European Union
Awarded by Center for Functional Neuroimaging Techniques
Funding Acknowledgements
National Institutes of Health (NIA P01 AG036694 to R.A.S. and K.A.J., K24AG035007 to R.A.S., and K01AG048287 to P.V.); Alzheimer's Association (IIRG-06-27374 to R.A.S.); European Union's Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie Grant agreement (IF-2015GF, 706714 to H.I.L.J.); Center for Functional Neuroimaging Techniques (P41EB015896). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.