Journal article

Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults

Federico d'Oleire Uquillas, Heidi IL Jacobs, Aaron P Schultz, Bernard J Hanseeuw, Rachel F Buckley, Jorge Sepulcre, Alvaro Pascual-Leone, Nancy J Donovan, Keith A Johnson, Reisa A Sperling, Patrizia Vannini

Cerebral Cortex | OXFORD UNIV PRESS INC | Published : 2020

Abstract

Judgments of learning (JOL) pertain to introspective metamemory processes evaluating how well information is learned. Using a functional magnetic resonance imaging (fMRI) task, we investigated the neural substrates of JOL predictions in a group of 105 cognitively unimpaired older adults from the Harvard Aging Brain Study. Associations of JOL performance and its neural correlates with amyloid-β (Aβ) and tau pathology, two proteinopathies associated with Alzheimer's disease (AD) and aging, were also examined. We found that trials judged as learned well relative to trials judged as learned less well (high JOL > low JOL) engaged the ventromedial prefrontal cortex and precuneus, among other midli..

View full abstract

Grants

Awarded by National Institutes of Health


Awarded by Alzheimer's Association


Awarded by European Union


Awarded by Center for Functional Neuroimaging Techniques


Funding Acknowledgements

National Institutes of Health (NIA P01 AG036694 to R.A.S. and K.A.J., K24AG035007 to R.A.S., and K01AG048287 to P.V.); Alzheimer's Association (IIRG-06-27374 to R.A.S.); European Union's Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie Grant agreement (IF-2015GF, 706714 to H.I.L.J.); Center for Functional Neuroimaging Techniques (P41EB015896). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.