Journal article

Individual participant data validation of the PICNICC prediction model for febrile neutropenia

Bob Phillips, Jessica Elizabeth Morgan, Gabrielle M Haeusler, Richard D Riley

Archives of Disease in Childhood | BMJ PUBLISHING GROUP | Published : 2020

Abstract

BACKGROUND: Risk-stratified approaches to managing cancer therapies and their consequent complications rely on accurate predictions to work effectively. The risk-stratified management of fever with neutropenia is one such very common area of management in paediatric practice. Such rules are frequently produced and promoted without adequate confirmation of their accuracy. METHODS: An individual participant data meta-analytic validation of the 'Predicting Infectious ComplicatioNs In Children with Cancer' (PICNICC) prediction model for microbiologically documented infection in paediatric fever with neutropenia was undertaken. Pooled estimates were produced using random-effects meta-analysis of ..

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Grants

Awarded by NIHR Post-Doctoral Fellowship award (NIHR Post-Doctoral Fellowship)


Funding Acknowledgements

This work was undertaken as part of an NIHR Post-Doctoral Fellowship award (NIHR Post-Doctoral Fellowship 10872).