Individual participant data validation of the PICNICC prediction model for febrile neutropenia
Bob Phillips, Jessica Elizabeth Morgan, Gabrielle M Haeusler, Richard D Riley
Archives of Disease in Childhood | BMJ PUBLISHING GROUP | Published : 2020
BACKGROUND: Risk-stratified approaches to managing cancer therapies and their consequent complications rely on accurate predictions to work effectively. The risk-stratified management of fever with neutropenia is one such very common area of management in paediatric practice. Such rules are frequently produced and promoted without adequate confirmation of their accuracy. METHODS: An individual participant data meta-analytic validation of the 'Predicting Infectious ComplicatioNs In Children with Cancer' (PICNICC) prediction model for microbiologically documented infection in paediatric fever with neutropenia was undertaken. Pooled estimates were produced using random-effects meta-analysis of ..View full abstract
Awarded by NIHR Post-Doctoral Fellowship award (NIHR Post-Doctoral Fellowship)
This work was undertaken as part of an NIHR Post-Doctoral Fellowship award (NIHR Post-Doctoral Fellowship 10872).