Central, prospective detection of homologous recombination repair gene mutations (HRRm) in tumour tissue from >4000 men with metastatic castration-resistant prostate cancer (mCRPC) screened for the PROfound study

Abstract

Background A proportion of patients (pts) with mCRPC have tumour cells harbouring HRRm that may confer sensitivity to PARP inhibition. The PROfound study (NCT02987543) is a phase III, randomized, multicentre trial evaluating the efficacy and safety of the PARP inhibitor olaparib versus physician’s choice of enzalutamide or abiraterone acetate in pre-treated mCRPC pts with a qualifying HRRm. Here we report the prevalence of HRRm and co-occurring HRRm in pts screened for PROfound. Methods An investigational next-generation sequencing assay developed in partnership with Foundation Medicine Inc. (FMI) was used to prospectively select patients harbouring HRRm in their tumour tissue. This tumour t..