Bacterial Load of Chlamydia trachomatis in the Posterior Oropharynx, Tonsillar Fossae, and Saliva among Men Who Have Sex with Men with Untreated Oropharyngeal Chlamydia
Tiffany R Phillips, Christopher K Fairley, Kate Maddaford, Jennifer Danielewski, Jane S Hocking, David Lee, Deborah A Williamson, Gerald Murray, Fabian Kong, Vesna De Petra, Catriona S Bradshaw, Marcus Y Chen, Rebecca Wigan, Anthony Snow, Benjamin P Howden, Suzanne M Garland, Eric PF Chow
Journal of Clinical Microbiology | AMER SOC MICROBIOLOGY | Published : 2020
The aim of this study was to determine whether Chlamydia trachomatis could be detected in saliva and if infection is specific to an anatomical site in the oropharynx. Men who have sex with men (MSM) who were diagnosed with oropharyngeal chlamydia at the Melbourne Sexual Health Centre in 2017-2018 were invited to participate upon returning for treatment. Swabs at the tonsillar fossae and posterior oropharynx and a saliva sample were collected. Throat samples were tested for C. trachomatis by the Aptima Combo 2 assay. The bacterial loads of C. trachomatis in all samples were assessed by quantitative PCR (qPCR) detecting the ompA gene. We calculated the positivity and bacterial load of C. trach..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) program grant
Awarded by NHMRC Early Career Fellowship
This work was funded by a National Health and Medical Research Council (NHMRC) program grant (GNT568971). E.P.F.C. was supported by an NHMRC Early Career Fellowship (GNT1091226).