Journal article

Increasing Respiratory Effort With 100% Oxygen During Resuscitation of Preterm Rabbits at Birth

Janneke Dekker, Stuart B Hooper, Michelle K Croughan, Kelly J Crossley, Megan J Wallace, Erin McGillick, Philip LJ DeKoninck, Marta Thio, Tessa Martherus, Gary Ruben, Charles C Roehr, Sophie JE Cramer, Andreas W Flemmer, Linda Croton, Arjan B te Pas, Marcus J Kitchen



Background: Spontaneous breathing is essential for successful non-invasive respiratory support delivered by a facemask at birth. As hypoxia is a potent inhibitor of spontaneous breathing, initiating respiratory support with a high fraction of inspired O2 may reduce the risk of hypoxia and increase respiratory effort at birth. Methods: Preterm rabbit kittens (29 days gestation, term ~32 days) were delivered and randomized to receive continuous positive airway pressure with either 21% (n = 12) or 100% O2 (n = 8) via a facemask. If apnea occurred, intermittent positive pressure ventilation (iPPV) was applied with either 21% or 100% O2 in kittens who started in 21% O2, and remained at 100% O2 fo..

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Awarded by National Health and Medical Research Council (NHMRC)

Awarded by NHMRC

Awarded by NWO innovational research incentives scheme

Awarded by Monash University Postdoctoral Fellowship

Awarded by NHMRC Peter Doherty Biomedical Early Career Fellowship

Awarded by ARC Future Fellowship

Awarded by Australian Government

Funding Acknowledgements

This research was supported by the National Health and Medical Research Council (NHMRC) Program Grant (606789), NHMRC Research Fellowships (SH: APP1058537, MT: APP1111134) and the Victorian Government's Operational Infrastructure Support Program. AP is recipient of an NWO innovational research incentives scheme (VIDI 91716428). EM was supported by a Monash University Postdoctoral Fellowship (BPF17-0066) and a NHMRC Peter Doherty Biomedical Early Career Fellowship (APP1138049). MK is a recipient of ARC Future Fellowship (FT160100454). We acknowledge travel funding provided by the International Synchrotron Access Program (ISAP) managed by the Australian Synchrotron and funded by the Australian Government (AS/IA173/12909 and ISP12221).