Journal article

Systemic inflammation suppresses lymphoid tissue remodelling and B cell immunity during concomitant local infection

Yannick Alexandre, Sapna Devi, Simone Park, Laura Mackay, William Heath, Scott Mueller

Cold Spring Harbor Laboratory | Published : 2019


Abstract Concurrent infection with multiple pathogens occurs frequently in individuals and can result in exacerbated infections and altered immunity. However, the impact of such coinfections on immune responses remains poorly understood. Here we reveal that systemic infection results in an inflammation-induced suppression of local immunity. During localized infection or vaccination in barrier tissues including the skin or respiratory tract, concurrent systemic infection induces a type I interferon-dependent lymphopenia that impairs lymphocyte recruitment to the draining lymph node (dLN). This leads to suppressed lymphoid stromal cell expansion and dLN remodelling and impaired induction of B ..

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