Early signal detection of adverse events following influenza vaccination using proportional reporting ratio, Victoria, Australia
Hazel J Clothier, Jock Lawrie, Melissa A Russell, Heath Kelly, Jim P Buttery
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2019
INTRODUCTION: Timely adverse event following immunisation (AEFI) signal event detection is essential to minimise further vaccinees receiving unsafe vaccines. We explored the proportional reporting ratio (PRR) ability to detect two known signal events with influenza vaccines with the aim of providing a model for prospective routine signal detection and improving vaccine safety surveillance in Australia. METHODS: Passive AEFI surveillance reports from 2008-2017 relating to influenza vaccines were accessed from the Australian SAEFVIC (Victoria) database. Proportional reporting ratios were calculated for two vaccine-event categories; fever and allergic AEFI. Signal detection sensitivity for two ..View full abstract
SAEFVIC is funded by the Department of Health and Human Services, Victoria. Hazel Clothier receives an Australian Government Research Training Program Scholarship. Authors HC, JL and JB are employees of SAEFVIC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.