Journal article

Quantitative Signal Intensity in Fluid-Attenuated Inversion Recovery and Treatment Effect in the WAKE-UP Trial

Bastian Cheng, Florent Boutitie, Alina Nickel, Anke Wouters, Tae-Hee Cho, Martin Ebinger, Matthias Endres, Jochen B Fiebach, Jens Fiehler, Ivana Galinovic, Josep Puig, Vincent Thijs, Robin Lemmens, Keith W Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z Simonsen Md, Christian Gerloff, Gotz Thomalla



Background and Purpose- Relative signal intensity of acute ischemic stroke lesions in fluid-attenuated inversion recovery (fluid-attenuated inversion recovery relative signal intensity [FLAIR-rSI]) magnetic resonance imaging is associated with time elapsed since stroke onset with higher intensities signifying longer time intervals. In the randomized controlled WAKE-UP trial (Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke Trial), intravenous alteplase was effective in patients with unknown onset stroke selected by visual assessment of diffusion weighted imaging fluid-attenuated inversion recovery mismatch, that is, in those with no marked fluid-attenuated inversion recovery h..

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University of Melbourne Researchers


Awarded by European Union Seventh Framework Program (FP7/2007-2013)

Funding Acknowledgements

WAKE-UP (Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke Trial) received funding from the European Union Seventh Framework Program (FP7/2007-2013) under grant agreement No. 278276 (WAKE-UP). This secondary analysis did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.