Journal article

An immune gate of depression - Early neuroimmune development in the formation of the underlying depressive disorder

Malgorzata Kowalczyk, Janusz Szemraj, Katarzyna Blizniewska, Michael Maes, Michael Berk, Kuan-Pin Su, Piotr Galecki

Pharmacological Reports | POLISH ACAD SCIENCES INST PHARMACOLOGY | Published : 2019

Abstract

The prevalence of depression worldwide is increasing from year to year and constitutes a serious medical, economic and social problem. Currently, despite multifactorial risk factors and pathways contributing to depression development, a significant aspect is attributed to the inflammatory process. Cytokines are considered a factor activating the kynurenine pathway, which leads to the exhaustion of tryptophan in the tryptophan catabolite (TRYCAT) pathway. This results in the activation of potentially neuroprogressive processes and also affects the metabolism of many neurotransmitters. The immune system plays a coordinating role in mediating inflammatory process. Beginning from foetal life, de..

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University of Melbourne Researchers