Journal article

Association between timing of diagnosis of trisomy 21, 18, and 13 and maternal socio-economic status in Victoria, Australia: A population-based cohort study from 2015 to 2016

Eliza Kluckow, Jane Halliday, Alice Poulton, Anthea Lindquist, Briohny Hutchinson, Michael Bethune, Leonard Bonacquisto, Fabricio Da Silva Costa, Lucy Gugasyan, James Harraway, Amanda Howden, Abhijit Kulkarni, Nicole Martin, Richard McCoy, Melody Menezes, Debbie Nisbet, Ricardo Palma-Dias, Mark D Pertile, Zeffie Poulakis, Lisa Hui

Prenatal Diagnosis | WILEY | Published : 2019

Abstract

OBJECTIVES: To explore the association between timing of diagnosis of common autosomal trisomies, maternal age, and socio-economic status (SES). DESIGN: Retrospective study of cytogenetic diagnoses of trisomy 21 (T21), trisomy 18 (T18), and trisomy 13 (T13) in Victoria, Australia, in 2015 to 2016, stratified by timing (prenatal less than 17 weeks gestation, prenatal including or greater than or 17 weeks gestation, and postnatal before 12 months of age), maternal age, and SES region. Utilisation of prenatal testing following a live-born T21 infant was ascertained via record linkage. RESULTS: Among 160 230 total births were 571 diagnoses of T21 and 246 of T18/T13. The overall and live birth pr..

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Grants

Awarded by National Health and Medical Research Council Senior Research Fellowship


Awarded by National Health and Medical Research Council Early Career Fellowship


Funding Acknowledgements

Murdoch Children's Research Institute; National Health and Medical Research Council Senior Research Fellowship, Grant/Award Number: 10121252; National Health and Medical Research Council Early Career Fellowship, Grant/Award Number: 1105603; Mercy Perinatal Research Fellowship