Journal article

Indirect Comparisons of Efficacy between Combination Approaches in Metastatic Hormone-sensitive Prostate Cancer: A Systematic Review and Network Meta-analysis

Niranjan J Sathianathen, Samantha Koschel, Isaac A Thangasamy, Jiasian Teh, Omar Alghazo, Georgiana Butcher, Harriet Howard, Jada Kapoor, Nathan Lawrentschuk, Shankar Siva, Arun Azad, Ben Tran, Damien Bolton, Declan G Murphy

European Urology | ELSEVIER | Published : 2020


CONTEXT: There have been substantial changes in the management of men with metastatic hormone-sensitive prostate cancer (mHSPC) over the past 5 yr, with upfront combination therapies replacing androgen-deprivation therapy (ADT) alone. A range of therapies have entered the space with no clear answer regarding their comparative efficacy. OBJECTIVE: To perform a systematic review and network meta-analysis to characterise the comparative efficacy of combination approaches in men with mHSPC. EVIDENCE ACQUISITION: We searched multiple databases and abstracts of major meetings up to June 2019 for randomised trials of patients receiving first-line therapy for metastatic disease, a combination of ADT..

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