Journal article

The Role of Zinc Efflux during Acinetobacter baumannii Infection

Saleh F Alquethamy, Felise G Adams, Varsha Naidu, Marian Khorvash, Victoria G Pederick, Maoge Zang, James C Paton, Ian T Paulsen, Karl A Hassan, Amy K Cain, Christopher A McDevitt, Bart A Eijkelkamp

ACS INFECTIOUS DISEASES | AMER CHEMICAL SOC | Published : 2020

Abstract

Acinetobacter baumannii is a ubiquitous Gram-negative bacterium, that is associated with significant disease in immunocompromised individuals. The success of A. baumannii is partly attributable to its high level of antibiotic resistance. Further, A. baumannii expresses a broad arsenal of putative zinc efflux systems that are likely to aid environmental persistence and host colonization, but detailed insights into how the bacterium deals with toxic concentrations of zinc are lacking. In this study we present the transcriptomic responses of A. baumannii to toxic zinc concentrations. Subsequent mutant analyses revealed a primary role for the resistance-nodulation-cell division heavy metal efflu..

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Grants

Awarded by National Health and Medical Research Council (Australia)


Awarded by Australian Research Council (ARC)


Awarded by NHMRC


Awarded by Channel 7 Children's Research Foundation


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (Australia) through Project Grant 1159752 to BAE and AKC, Project Grants 1080784 and 1122582 to CAM and Program Grant 1071659 to JCP. The work was also funded by the Australian Research Council (ARC) Discovery Project Grant DP170102102 to JCP and CAM. Work performed by KAH and ITP is supported by NHMRC Project grant 1120298. BAE and CAM are supported by a Channel 7 Children's Research Foundation Grant (161203). BAE is a University of Adelaide Beacon Research Fellow and CAM is an ARC Future Fellow (FT170100006). This work was supported by the University of Melbourne (Research Training Program Scholarship to SFA).