Journal article

Patients with end-stage kidney disease have markedly abnormal cortical hip parameters by dual-energy X-ray absorptiometry

Jasna Aleksova, Frances Milat, Mark A Kotowicz, Julie A Pasco, Chris Schultz, Phillip Wong, Peter R Ebeling, Grahame J Elder

Nephrology Dialysis Transplantation | OXFORD UNIV PRESS | Published : 2021

Abstract

BACKGROUND: Patients with end-stage kidney disease (ESKD) have higher fracture rates and post-fracture mortality than the general population, but bone mineral density by dual-energy X-ray absorptiometry (DXA) is less predictive of fracture in this patient group. Bone biopsy and high-resolution imaging indicate that cortical thickness (CT) is reduced and cortical porosity is increased in ESKD. The aim of this study was to assess cortical parameters using DXA in patients with ESKD. It was hypothesized that these parameters would show deterioration and be associated with fracture. METHODS: Using advanced hip analysis, normal age-related ranges were determined from 752 female and 861 male femur ..

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University of Melbourne Researchers