Periconceptional ethanol exposure induces a sex specific diuresis and increase in AQP2 and AVPR2 in the kidneys of aged rat offspring
Emily S Dorey, Sarah L Walton, Jacinta Kalisch-Smith, Tamara M Paravicini, Emelie M Gardebjer, Kristy A Weir, Reetu R Singh, Helle Bielefeldt-Ohmann, Stephen T Anderson, Mary E Wlodek, Karen M Moritz
Physiological Reports | WILEY | Published : 2019
Maternal alcohol consumption can impair renal development and program kidney dysfunction in offspring. Given that most women who drink alcohol cease consumption upon pregnancy recognition, we aimed to investigate the effect of alcohol around the time of conception (PC:EtOH) on offspring renal development and function. Rats received a liquid diet ±12.5% v/v ethanol from 4 days before to 4 days after mating. At postnatal day 30, nephron number was assessed. Urine flow and electrolyte (Na, K, Cl) excretion was measured at 6 and 19 months and blood pressure at 12 months. At 19 months, kidneys were collected for gene and protein analysis and assessment of collecting duct length. At postnatal day ..View full abstract
Awarded by National Health and Medical Research Council of Australia
Awarded by NHMRC
This work was funded by a research grant from the National Health and Medical Research Council of Australia (APP1046137). ED, JKS, SW were each funded by an Australian Postgraduate Award. KM was funded by a NHMRC Senior Research Fellowship (APP1078164).