Journal article

Magnetic resonance enterography for predicting the clinical course of Crohn's disease strictures

Julien D Schulberg, Emily K Wright, Bronte A Holt, Tom R Sutherland, Simon J Hume, Amy L Hamilton, Alyson L Ross, William C Connell, Steven J Brown, Mark Lust, Ashley M Miller, Sally J Bell, Michael A Kamm

Journal of gastroenterology and hepatology | WILEY | Published : 2019

Abstract

BACKGROUND AND AIMS: Strictures are the most common Crohn's disease complication, but their natural history is unknown. This study aimed to characterize inflammation, predict prognosis, and understand the impact of drug therapy using magnetic resonance enterography (MRE). METHODS: Patients with a stricture diagnosed on MRE over a 5-year period were reviewed for MRE disease extent and inflammation, clinical course, C-reactive protein, response to anti-TNF therapy, endoscopic dilatation, hospitalization, and surgery. RESULTS: 136 patients had 235 (77, one and 59, ≥ 2) strictures. TREATMENT: 46% of patients underwent surgery after a median 6 months; median follow-up for those not requiring surg..

View full abstract

Grants

Funding Acknowledgements

The National Health and Medical Research Council supported JDS and BAH. GESA/Ferring IBD Clinician Establishment Award supported EKW. Australasian Gastro Intestinal Research Foundation, AbbVie and the Spotlight Foundation supported the Project.