Journal article

Relative Seizure Relapse Risks Associated with Antiepileptic Drug Withdrawal After Different Seizure-Free Periods in Adults with Focal Epilepsy: A Prospective, Controlled Follow-Up Study

Xinshi Wang, Ruqian He, Rongyuan Zheng, Siqi Ding, Yi Wang, Xueying Li, Yingjie Hua, Qingyi Zeng, Niange Xia, Zhenguo Zhu, Patrick Kwan, Huiqin Xu

CNS Drugs | ADIS INT LTD | Published : 2019

Abstract

BACKGROUND: Approximately two-thirds of patients with newly diagnosed epilepsy become seizure-free after antiepileptic drug (AED) treatment. A crucial issue for these patients and their families, especially after a long period of seizure freedom, is when to stop their medications. OBJECTIVE: The aim of this study was to identify the optimal timing of AED withdrawal in adults with focal epilepsy who had been seizure-free for ≥ 2 years. METHODS: Adults with focal epilepsy who had been seizure-free for ≥ 2 years were recruited. Based on their decision to discontinue (withdrawal) or continue (non-withdrawal) AED treatment, patients were assigned to withdrawal or non-withdrawal subgroups accordin..

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