Journal article

Relative Seizure Relapse Risks Associated with Antiepileptic Drug Withdrawal After Different Seizure-Free Periods in Adults with Focal Epilepsy: A Prospective, Controlled Follow-Up Study

Xinshi Wang, Ruqian He, Rongyuan Zheng, Siqi Ding, Yi Wang, Xueying Li, Yingjie Hua, Qingyi Zeng, Niange Xia, Zhenguo Zhu, Patrick Kwan, Huiqin Xu

CNS Drugs | ADIS INT LTD | Published : 2019

Abstract

BACKGROUND: Approximately two-thirds of patients with newly diagnosed epilepsy become seizure-free after antiepileptic drug (AED) treatment. A crucial issue for these patients and their families, especially after a long period of seizure freedom, is when to stop their medications. OBJECTIVE: The aim of this study was to identify the optimal timing of AED withdrawal in adults with focal epilepsy who had been seizure-free for ≥ 2 years. METHODS: Adults with focal epilepsy who had been seizure-free for ≥ 2 years were recruited. Based on their decision to discontinue (withdrawal) or continue (non-withdrawal) AED treatment, patients were assigned to withdrawal or non-withdrawal subgroups accordin..

View full abstract

Grants

Awarded by China Scholarship Council


Awarded by Zhejiang Medical and Health Science and Technology Project


Funding Acknowledgements

This research was partly supported by the China Scholarship Council (Grant no. 201808330160, to XW) and the Zhejiang Medical and Health Science and Technology Project (grant no. 2019320104, to XW).