The Nargenicin Family of Oxa-Bridged Macrolide Antibiotics
Sacha J Pidot, Mark A Rizzacasa
Chemistry – A European Journal | WILEY-V C H VERLAG GMBH | Published : 2019
The nargenicin family of antibiotic macrolides comprise a group of bacterial natural products with a rare ether bridged cis-decalin moiety and a narrow spectrum of activity. Most family members were identified almost four decades ago and were placed on the shelf due to the numbers of broad-spectrum compounds available at the time. However, in light of rising rates of antimicrobial resistance, there has been a renewed interest in the use of narrow-spectrum antimicrobials. Here, we review the history of this family of compounds, including synthetic approaches, and highlight the recently uncovered genetic basis for nargenicin production. Given the renewed pharmaceutical interest in these compou..View full abstract
Awarded by Australian National Health and Medical Research Council
This work was supported by an Australian National Health and Medical Research Council grant GNT1105522.