Journal article

Cortical thinning in dementia with Lewy bodies and Parkinson disease dementia

Sean J Colloby, Rosie Watson, Andrew M Blamire, John T O'Brien, John-Paul Taylor

Australian and New Zealand Journal of Psychiatry | SAGE PUBLICATIONS LTD | Published : 2019


BACKGROUND: We investigated the structural changes associated with Alzheimer's disease, dementia with Lewy bodies and Parkinson disease dementia by means of cortical thickness analysis. METHODS: Two hundred and forty-five participants: 76 Alzheimer's disease, 65 dementia with Lewy bodies, 29 Parkinson disease dementia and 76 cognitively normal controls underwent 3-T T1-weighted magnetic resonance imaging and clinical and cognitive assessments. We implemented FreeSurfer to obtain cortical thickness estimates to contrast patterns of cortical thinning across groups and their clinical correlates. RESULTS: In Alzheimer's disease and dementia with Lewy bodies, a largely similar pattern of regional..

View full abstract


Awarded by Wellcome Trust

Awarded by Sir Jules Thorn Charitable Trust

Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: Financial support was from the National Institute for Health Research (NIHR) Research for Public Benefit, Wellcome Trust (WT088441MA Fellowship funding J-P.T). NIHR Biomedical Research Centre at Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge. The NIHR Newcastle Biomedical Research Centre in Ageing and Chronic Disease and Biomedical Research Unit in Lewy Body Dementia based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University. The study was also funded by the Sir Jules Thorn Charitable Trust (Grant ref: 05/JTA).