Journal article

Plasmodium vivax Malaria Viewed through the Lens of an Eradicated European Strain

Lucy van Dorp, Pere Gelabert, Adrien Rieux, Marc de Manuel, Toni de-Dios, Shyam Gopalakrishnan, Christian Caroe, Marcela Sandoval-Velasco, Rosa Fregel, Inigo Olalde, Raul Escosa, Carles Aranda, Silvie Huijben, Ivo Mueller, Tomas Marques-Bonet, Francois Balloux, M Thomas P Gilbert, Carles Lalueza-Fox

Molecular Biology and Evolution | OXFORD UNIV PRESS | Published : 2020

Abstract

The protozoan Plasmodium vivax is responsible for 42% of all cases of malaria outside Africa. The parasite is currently largely restricted to tropical and subtropical latitudes in Asia, Oceania, and the Americas. Though, it was historically present in most of Europe before being finally eradicated during the second half of the 20th century. The lack of genomic information on the extinct European lineage has prevented a clear understanding of historical population structuring and past migrations of P. vivax. We used medical microscope slides prepared in 1944 from malaria-affected patients from the Ebro Delta in Spain, one of the last footholds of malaria in Europe, to generate a genome of a E..

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University of Melbourne Researchers

Grants

Awarded by Obra Social "La Caixa," Secretaria d'Universitats i Recerca Programme del Departament d'Economia i Coneixement de la Generalitat de Catalunya


Awarded by Obra Social "La Caixa," Secretaria d'Universitats i Recerca


Awarded by FEDER-Ministry of Science, Innovation and Universities (MCIU)


Awarded by European Research Council (ERC) Consolidator Grant


Awarded by Newton Fund UKChina NSFC initiative


Awarded by Biotechnology and Biological Sciences Research Council (BBSRC)


Awarded by ENA BioProject


Funding Acknowledgements

We are grateful to Thomas D. Otto (University of Glasgow) and Thomas Lavsten (University of Copenhagen) for helpful comments and suggestions and to the descendants of Dr Canicio, Miquel, and IldefonsOliveras for sharing with us their slides. We additionally would like to thank Dr George Busby and Dr Jacob Almagro for useful discussions on chromosome painting of Plasmodium sp. This research was supported by a grant from Obra Social "La Caixa," Secretaria d'Universitats i Recerca Programme del Departament d'Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 880), Secretaria d'Universitats i Recerca (GRC2017SGR880), and by FEDER-Ministry of Science, Innovation and Universities (MCIU) (PGC2018-095931-B-100) to C.L.-F. and an European Research Council (ERC) Consolidator Grant (681396-Extinction Genomics) to M.T.P.G. L.v.D., and F.B. acknowledge financial support from the Newton Fund UKChina NSFC initiative (grant MR/P007597/1) and the Biotechnology and Biological Sciences Research Council (BBSRC) (equipment grant BB/R01356X/1). Plasmodium vivax genomes are deposited with ENA BioProject ID PRJEB30878. We also thank the Danish National High Throughput Sequencing Centre for help in sequencing.