Journal article

A rapid triage test for active pulmonary tuberculosis in adult patients with persistent cough

Rushdy Ahmad, Liangxia Xie, Margaret Pyle, Marta F Suarez, Tobias Broger, Dan Steinberg, Shaali M Ame, Marilla G Lucero, Matthew J Szucs, Melanie MacMullan, Frode S Berven, Arup Dutta, Diozele M Sanvictores, Veronica L Tallo, Robert Bencher, Dominic P Eisinger, Usha Dhingra, Saikat Deb, Said M Ali, Saurabh Mehta Show all

Science Translational Medicine | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2019

Abstract

Improved tuberculosis (TB) prevention and control depend critically on the development of a simple, readily accessible rapid triage test to stratify TB risk. We hypothesized that a blood protein-based host response signature for active TB (ATB) could distinguish it from other TB-like disease (OTD) in adult patients with persistent cough, thereby providing a foundation for a point-of-care (POC) triage test for ATB. Three adult cohorts consisting of ATB suspects were recruited. A bead-based immunoassay and machine learning algorithms identified a panel of four host blood proteins, interleukin-6 (IL-6), IL-8, IL-18, and vascular endothelial growth factor (VEGF), that distinguished ATB from OTD...

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Grants

Awarded by Grand Challenge in Global Health grant from the Bill and Melinda Gates Foundation


Funding Acknowledgements

This work was supported in part by a Grand Challenge in Global Health grant from the Bill and Melinda Gates Foundation for the study titled "Population Health Metrics Research Consortium Project" (contract no. 041222241) (to S.A.C).