A rapid triage test for active pulmonary tuberculosis in adult patients with persistent cough
Rushdy Ahmad, Liangxia Xie, Margaret Pyle, Marta F Suarez, Tobias Broger, Dan Steinberg, Shaali M Ame, Marilla G Lucero, Matthew J Szucs, Melanie MacMullan, Frode S Berven, Arup Dutta, Diozele M Sanvictores, Veronica L Tallo, Robert Bencher, Dominic P Eisinger, Usha Dhingra, Saikat Deb, Said M Ali, Saurabh Mehta Show all
Science Translational Medicine | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2019
Improved tuberculosis (TB) prevention and control depend critically on the development of a simple, readily accessible rapid triage test to stratify TB risk. We hypothesized that a blood protein-based host response signature for active TB (ATB) could distinguish it from other TB-like disease (OTD) in adult patients with persistent cough, thereby providing a foundation for a point-of-care (POC) triage test for ATB. Three adult cohorts consisting of ATB suspects were recruited. A bead-based immunoassay and machine learning algorithms identified a panel of four host blood proteins, interleukin-6 (IL-6), IL-8, IL-18, and vascular endothelial growth factor (VEGF), that distinguished ATB from OTD...View full abstract
Awarded by Grand Challenge in Global Health grant from the Bill and Melinda Gates Foundation
This work was supported in part by a Grand Challenge in Global Health grant from the Bill and Melinda Gates Foundation for the study titled "Population Health Metrics Research Consortium Project" (contract no. 041222241) (to S.A.C).