Journal article

Early-Life Exposure to Oral Antibiotics and Lung Function Into Early Adulthood

Karoliny dos Santos, Caroline J Lodge, Michael J Abramson, Bircan Erbas, Catherine M Bennett, Jennie Hui, Shyamali C Dharmage, Adrian J Lowe

CHEST Journal | ELSEVIER | Published : 2020

Abstract

BACKGROUND: Although there is ongoing debate regarding the impact of early postnatal exposure to antibiotics on the development of asthma, the possibility that antibiotic exposure may impair lung function has not previously been examined. Furthermore, it is unclear if specific types of antibiotics may have a greater effect, or if children with genetic mutations in the oxidative stress response glutathione S-transferase (GST) superfamily may be at greater risk. METHODS: Parent-reported data of childhood antibiotic use from birth to 2 years, including type and indication, were collected from a birth cohort of 620 infants with a family history of allergy. Spirometry was performed at age 12 and ..

View full abstract

Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by CAPES [Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brazil]


Funding Acknowledgements

The first 6 years of the Melbourne Atopy Cohort Study (MACS) were funded (study formula and staff) by Nestec Ltd., a subsidiary of Nestle Australia. The 12-year follow-up was funded by a project grant from the Asthma Foundation of Victoria. The National Health and Medical Research Council of Australia funded the 18-year follow-up [APP454856]. Support was also provided by CAPES [Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brazil, scholarship Karoliny dos Santos/Programa de Doutorado Sanduiche no Exterior/process number 88881.135266/2016-01].