Journal article
Coagulation abnormalities, bleeding, thrombosis, and management of patients with acute liver failure in Australia and New Zealand
S Warrillow, C Fisher, H Tibballs, M Bailey, C McArthur, P Lawson-Smith, B Prasad, M Anstey, B Venkatesh, G Dashwood, J Walsham, A Holt, U Wiersema, D Gattas, M Zoeller, M Garcia Alvarez, R Bellomo
Journal of Gastroenterology and Hepatology Australia | WILEY | Published : 2020
DOI: 10.1111/jgh.14876
Abstract
Background and Aim: To study the management of coagulation and hematological derangements among severe acute liver failure (ALF) patients in Australia and New Zealand liver transplant intensive care units (ICUs). Methods: Analysis of key baseline characteristics, etiology, coagulation and hematological tests, use of blood products, thrombotic complications, and clinical outcomes during the first ICU week. Results: We studied 62 ALF patients. The first day median peak international normalized ratio was 5.5 (inter-quartile range [IQR] 3.8–8.7), median longest activated partial thromboplastin time was 62 s (IQR 44–87), and median lowest fibrinogen was 1.1 (IQR 0.8–1.6) g/L. Fibrinogen was only ..
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