Journal article

Stroke Severity, and Not Cerebral Infarct Location, Increases the Risk of Infection

Raymond Shim, Shu Wen Wen, Brooke J Wanrooy, Michelle Rank, Tharani Thirugnanachandran, Luke Ho, Tara Sepehrizadeh, Michael de Veer, Velandai K Srikanth, Henry Ma, Thanh G Phan, Christopher G Sobey, Connie HY Wong

TRANSLATIONAL STROKE RESEARCH | SPRINGER | Published : 2019

Abstract

Infection is a leading cause of death in patients with stroke; however, the impact of cerebral infarct size or location on infectious outcome is unclear. To examine the effect of infarct size on post-stroke infection, we utilised the intraluminal middle-cerebral artery occlusion (MCAO) mouse model of ischemic stroke and adjusted the duration of arterial occlusion. At 1 day following stroke onset, the proportion of mice with infection was significantly greater in mice that had larger infarct sizes. Additionally, the presence of lung infection in these mice with severe strokes extended past 2 days, suggestive of long-term immune impairment. At the acute phase, our data demonstrated an inverse ..

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Grants

Awarded by National Heart Foundation (NHF, Australia)


Awarded by National Health and Medical Research Council (NHMRC, Australia)


Funding Acknowledgements

This work is supported by the National Heart Foundation (NHF, Australia; 100,863), CSL Centenary Fellowship and the National Health and Medical Research Council (NHMRC, Australia: APP1104036). The financial supports have no role in conducting the research and/or preparation of the article.