The proteasome as a target for protozoan parasites
Stanley C Xie, Lawrence R Dick, Alexandra Gould, Stephen Brand, Leann Tilley
Expert Opinion on Therapeutic Targets | TAYLOR & FRANCIS LTD | Published : 2019
Introduction: The proteasome is a multi-subunit enzyme complex responsible for the turnover of short-lived, abnormal or damaged proteins in eukaryotic cells. As organisms that undergo rapid growth and cell division, protozoan parasites exist on the knife-edge of proteotoxic catastrophe and thus rely heavily on their protein quality control machinery for survival. Because of this, the proteasome has recently emerged as a desirable drug target.Area covered: This review focuses on efforts to identify protozoan parasite-specific proteasome inhibitors using substrate profiling, library screening, and in vitro evolution of resistance approaches to inform medicinal chemistry. Targeting the parasite..View full abstract
This work was supported by the Global Health Innovative Technology Fund.