Journal article

Development of the intrinsic innervation of the small bowel mucosa and villi

Marlene M Hao, Candice Fung, Werend Boesmans, Katrien Lowette, Jan Tack, Pieter Vanden Berghe

American Journal of Physiology-Gastrointestinal and Liver Physiology | AMER PHYSIOLOGICAL SOC | Published : 2020


Detection of nutritional and noxious food components in the gut is a crucial component of gastrointestinal function. Contents in the gut lumen interact with enteroendocrine cells dispersed throughout the gut epithelium. Enteroendocrine cells release many different hormones, neuropeptides, and neurotransmitters that communicate either directly or indirectly with the central nervous system and the enteric nervous system, a network of neurons and glia located within the gut wall. Several populations of enteric neurons extend processes that innervate the gastrointestinal lamina propria; however, how these processes develop and begin to transmit information from the mucosa is not fully understood..

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University of Melbourne Researchers


Awarded by FWO Project

Awarded by KU Leuven Methusalem Grant

Awarded by Hercules Foundation Flanders

Funding Acknowledgements

This work was supported by FWO Project Grant G092115N to P.Vanden Berghe, W. Boesmans, M. M. Hao and KU Leuven Methusalem Grant (METH/14/05) to J. Tack and P. Vanden Berghe. Confocal microscopes were funded by the Hercules Foundation Flanders (AKUL/11/37, AKUL/13/37 and AKUL/15/37 to PVB). M. M. Hao is a postdoctoral fellow of the NHMRC (APP1655567) and FWO (12G1214N). W. Boesmans was a postdoctoral fellow of the FWO (1233514N).