Chronic isolation stress is associated with increased colonic and motor symptoms in the A53T mouse model of Parkinson's disease
Shanti Diwakarla, David I Finkelstein, Remy Constable, Olivia Artaiz, Madeleine Di Natale, Rachel M McQuade, Enie Lei, Xin-yi Chai, Mitchell T Ringuet, Linda J Fothergill, Victoria A Lawson, Laura J Ellett, Joel P Berger, John B Furness
NEUROGASTROENTEROLOGY AND MOTILITY | WILEY | Published : 2019
BACKGROUND: Chronic stress exacerbates motor deficits and increases dopaminergic cell loss in several rodent models of Parkinson's disease (PD). However, little is known about effects of stress on gastrointestinal (GI) dysfunction, a common non-motor symptom of PD. We aimed to determine whether chronic stress exacerbates GI dysfunction in the A53T mouse model of PD and whether this relates to changes in α-synuclein distribution. METHODS: Chronic isolation stress was induced by single-housing WT and homozygote A53T mice between 5 and 15 months of age. GI and motor function were compared with mice that had been group-housed. KEY RESULTS: Chronic isolation stress increased plasma corticosterone..View full abstract
Awarded by National Health and Medical Research Council
This work was supported by funding from Takeda Pharmaceuticals International Inc and the National Health and Medical Research Council (grant APP1145686).