Conference Proceedings
Childhood wheeze phenotypes and atopy over adolescence
Caroline Lodge, Adrian Lowe, Katrina Allen, Melanie Matheson, Paul Thomas, Catherine Bennett, Christine Axelrad, Bircan Erbas, Cecilie Svanes, David Hill, Clifford Hosking, Michael Abramson, S Dharmage
EUROPEAN RESPIRATORY JOURNAL | EUROPEAN RESPIRATORY SOC JOURNALS LTD | Published : 2014
Abstract
Background Atopy is linked with asthma severity and persistence in childhood, but adolescent atopic outcomes of wheeze phenotypes defined by latent class analysis (LCA) are unknown. Aim Determine adolescent atopic outcomes of LCA defined childhood wheeze phenotypes (0-7 years) Method A high-atopy risk birth cohort recorded atopic outcomes (sensitization, eczema, hay fever and expired Nitric oxide [eNO]) at 12(N=375) and/or 18 years(N=411). Regression analyses investigated associations between atopic outcomes and phenotypes of: Early Transient, Early Persistent, Intermediate Onset and Late Onset wheeze, ..
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