Journal article
Regional differences in infection and structural lung disease in infants and young children with cystic fibrosis
R Carzino, KB Frayman, L King, S Vidmar, S Ranganathan
Journal of Cystic Fibrosis | ELSEVIER | Published : 2020
Abstract
Background: Both infection and inflammation are critical to the progression of cystic fibrosis (CF) lung disease. Potential anatomical differences in lower airway infection, inflammation and bronchiectasis in young children with CF raise questions regarding the pathogenesis of early structural lung disease. Methods: A longitudinal multi-centre birth cohort study of infants newly diagnosed with CF was conducted. Paired bronchoalveolar lavage (BAL) samples were obtained from the right middle lobe (RML) and lingula bronchi. Chest computed tomography (CT) was performed biennially and analysed using the modified CF-CT scoring system. Results: One hundred and twenty-four children (0.11 - 7.0 years..
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Awarded by Murdoch Children's Research Institute
Funding Acknowledgements
[ "AREST CF study supported by the National Health and Medical Research Council grants (APP1043768, APP1162775)", "SR was supported by the Clinician Scientist award by Murdoch Children's Research Institute.", "KBF was supported by the Thoracic Society of Australia and New Zealand Vertex Cystic Fibrosis Paediatric Clinical Fellowship, the RCH CFRT, the Australian Cystic Fibrosis Research Trust Postgraduate Studentship, an Australian National Health and Medical Research Council (NHMRC) postgraduate scholarship, a Royal Australasian College of Physicians Paediatrics and Child Health Division NHMRC Award for Excellence (Top-up), the Clifford Family PhD Scholarship and an Australian Government Research Training Program Scholarship." ]