Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

MA Hossain; F Larrous; SM Rawlinson; J Zhan; A Sethi; Y Ibrahim; M Aloi; KG Lieu; YF Mok; MDW Griffin; N Ito; T Ose; H Bourhy; GW Moseley; PR Gooley

Journal article

Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

MA Hossain, F Larrous, SM Rawlinson, J Zhan, A Sethi, Y Ibrahim, M Aloi, KG Lieu, YF Mok, MDW Griffin, N Ito, T Ose, H Bourhy, GW Moseley, PR Gooley

Cell Reports | CELL PRESS | Published : 2019

DOI: 10.1016/j.celrep.2019.10.020

Abstract

Hossain et al. explore the binding surface of the multifunctional P-protein of rabies virus for STAT1, a protein that is essential for establishing the antiviral response of infected cells. They identify a complex interface comprising several distinct sites and demonstrate that targeted modifications of these can significantly attenuate pathogenic virus.

University of Melbourne Researchers

Ashish Sethi Author

Yee Foong Mok Author

Michael Griffin Author

Paul Gooley Author

Grants

Awarded by University of Melbourne

Funding Acknowledgements

We thank Cassandra David for assistance with tissue culture, the Monash Micro Imaging facility (Monash University), and the nuclear magnetic resonance facility (University of Melbourne; Australian Research Council equipment grant LE120100022). This work was supported by National Health and Medical Research Council grant 1125704 to G.W.M., P.R.G., and H.B. and grants 1160838, 1079211, and 1003244 to G.W.M., and Australian Research Council grant DP150102569 to G.W.M.; a Grimwade Fellowship provided by the Meigunyah Fund to G.W.M.; and Japanese Society for the Promotion of Science fellowships S11102 and L14563 to G.W.M.