Journal article

Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology

Masayuki Ide, Tetsuo Ohnishi, Manabu Toyoshima, Shabeesh Balan, Motoko Maekawa, Chie Shimamoto-Mitsuyama, Yoshimi Iwayama, Hisako Ohba, Akiko Watanabe, Takashi Ishii, Norihiro Shibuya, Yuka Kimura, Yasuko Hisano, Yui Murata, Tomonori Hara, Momo Morikawa, Kenji Hashimoto, Yayoi Nozaki, Tomoko Toyota, Yuina Wada Show all

EMBO Molecular Medicine | WILEY | Published : 2019

Grants

Awarded by Japan Agency for Medical Research and Development (AMED)


Awarded by MEXT


Awarded by JSPS KAKENHI


Funding Acknowledgements

We deeply thank Yuko Fukata (National Institute for Physiological Sciences) for valuable suggestions regarding the palmitoylation assay. We are grateful to Noriyuki Nagahara (Nippon Medical School) for kindly providing the anti-Mpst polyclonal antibody (Nagahara et al, 1998). pCAGGS (Niwa et al, 1991) was provided by the RIKEN BRC through the National BioResource Project of the MEXT/AMED, Japan. We also thank members of Research Resources Division, RIKEN CBS, for animal maintenance, embryo manipulation, metabolite analysis and DNA sequencing service, Takashi Asada for his help for the establishment of collaborative team, Miyuki Kato and Santha Kumara Dissanayaka for technical assistance, Atsuko Nagata, Junya Matsumoto and Mizuki Hino for the preparation of postmortem brain samples, Tomoe Ichikawa, Kazuya Toriumi and Akiko Kobori for their help for collecting scalp hair follicle samples, Masaomi Iyo and Toshihisa Niitsu for collecting plasma samples, Tadayuki Ogawa for his help for spine analysis, and Makoto Asashima and Renpei Nagashima for their helpful comments and discussions. This study was supported by the Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and Development (AMED) under Grant Numbers JP18dm0107083 (TY), JP19dm0107083 (TY), JP18dm0107085 (HK), JP19dm0107119 (KH), JP19dm0908001 (NH), 19dm0107086 (YKu), and 19dm0107107 (HY), and by the Grant-in-Aid for Scientific Research on Innovative Areas from the MEXT under Grant Numbers JP18H05435 (TY), JP18H05428 (TY), and JP16H06277 (HY), and by JSPS KAKENHI under Grant Number JP17H01574 (TY). This study was also supported in part by Grants-in-Aid for NEDO (New Energy and Industrial Technology Development Organization) (KU). This work was performed in part as a collaborative research effort of Clinical Bioinformatics Research Initiative (CBIRI) at the National Institute of Advanced Industrial Science and Technology (AIST), Japan.