Journal article

Presymptomatic Retinal Sensitivity Changes in Intermediate Age-Related Macular Degeneration Associated With New Retinal Fluid

Antony J Wightman, Carla J Abbott, Myra B McGuinness, Emily Caruso, Robyn H Guymer, Chi D Luu

Translational Vision Science & Technology | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2019

Abstract

Purpose: To determine whether change in retinal sensitivity in areas with subretinal or intraretinal fluid secondary to age-related macular degeneration (AMD) precedes visual symptoms. If confirmed, retinal sensitivity testing could be used for home monitoring in AMD. Methods: Individuals with intermediate AMD enrolled in a longitudinal study were seen every 6 months and underwent best-corrected visual acuity testing (BCVA), spectral domain-optical coherence tomography (SD-OCT), and microperimetry. Asymptomatic individuals who developed incidental, reading center-determined retinal fluid detected on SD-OCT were identified. The point-wise sensitivity (PWS) at the time of fluid detection was c..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) Fellowship


Awarded by NHMRC


Funding Acknowledgements

Supported by National Health and Medical Research Council (NHMRC) Fellowship (#1103013, RHG) and NHMRC Project Grant (1084081). The Centre for Eye Research Australia (CERA) receives operational infrastructure support from the Victorian State Government.