Auditory prediction errors and auditory white matter microstructure associated with psychotic-like experiences in healthy individuals
LKL Oestreich, R Randeniya, M Garrido
Brain Structure and Function | SPRINGER HEIDELBERG | Published : 2019
Our sensory systems actively predict sensory information based on previously learnt patterns, which are continuously updated with information from the actual sensory input via prediction errors. Individuals with schizophrenia consistently show reduced auditory prediction errors as well as altered fractional anisotropy (indicative of white matter changes) in the arcuate fasciculus and the auditory interhemispheric pathway, both of which are auditory white matter pathways associated with prediction errors. However, it is not clear if healthy individuals with psychotic-like experiences exhibit similar deficits. Participants underwent electroencephalography (EEG) recordings while listening to a ..View full abstract
Awarded by UQ Fellowship
Awarded by UQ Foundation Research Excellence Award
Awarded by ARC Centre of Excellence for Integrative Brain Function
We thank John McGrath for helpful discussions; David Lloyd, Elise Rowe for support in EEG data acquisition. Aiman Al-Najjar and Nicole Atcheson for assisting in MRI data collection, and all participants for their time. M.I.G. was supported by a UQ Fellowship (2016000071), a UQ Foundation Research Excellence Award (2016001844), and the ARC Centre of Excellence for Integrative Brain Function (ARC CE140100007). R.R. was supported through a UQ International Research Scholarship.