Genomic Analysis of Fluoroquinolone- and Tetracycline-Resistant Campylobacter jejuni Sequence Type 6964 in Humans and Poultry, New Zealand, 2014-2016
Nigel P French, Ji Zhang, Glen P Carter, Anne C Midwinter, Patrick J Biggs, Kristin Dyet, Brent J Gilpin, Danielle J Ingle, Kerry Mulqueen, Lynn E Rogers, David A Wilkinson, Sabrina S Greening, Petra Muellner, Ahmed Fayaz, Deborah A Williamson
Emerging Infectious Diseases | CENTERS DISEASE CONTROL & PREVENTION | Published : 2019
In 2014, antimicrobial drug-resistant Campylobacter jejuni sequence type 6964 emerged contemporaneously in poultry from 3 supply companies in the North Island of New Zealand and as a major cause of campylobacteriosis in humans in New Zealand. This lineage, not previously identified in New Zealand, was resistant to tetracycline and fluoroquinolones. Genomic analysis revealed divergence into 2 major clades; both clades were associated with human infection, 1 with poultry companies A and B and the other with company C. Accessory genome evolution was associated with a plasmid, phage insertions, and natural transformation. We hypothesize that the tetO gene and a phage were inserted into the chrom..View full abstract
Funding was provided by the Ministry of Health, New Zealand; the Ministry for Primary Industries, New Zealand; and the Poultry Industry Association of New Zealand.