Association of Adverse Outcomes with Emotion Processing and Its Neural Substrate in Individuals at Clinical High Risk for Psychosis

G Modinos; MJ Kempton; S Tognin; M Calem; L Porffy; M Antoniades; A Mason; M Azis; P Allen; B Nelson; P McGorry; C Pantelis; A Riecher-Rössler; S Borgwardt; R Bressan; N Barrantes-Vidal; MO Krebs; M Nordentoft; B Glenthøj; S Ruhrmann; G Sachs; B Rutten; J Van Os; L De Haan; E Velthorst; M Van Der Gaag; LR Valmaggia; P McGuire

Journal article

Association of Adverse Outcomes with Emotion Processing and Its Neural Substrate in Individuals at Clinical High Risk for Psychosis

G Modinos, MJ Kempton, S Tognin, M Calem, L Porffy, M Antoniades, A Mason, M Azis, P Allen, B Nelson, P McGorry, C Pantelis, A Riecher-Rössler, S Borgwardt, R Bressan, N Barrantes-Vidal, MO Krebs, M Nordentoft, B Glenthøj, S Ruhrmann Show all

JAMA Psychiatry | AMER MEDICAL ASSOC | Published : 2020

DOI: 10.1001/jamapsychiatry.2019.3501

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Abstract

Importance: The development of adverse clinical outcomes in patients with psychosis has been associated with behavioral and neuroanatomical deficits related to emotion processing. However, the association between alterations in brain regions subserving emotion processing and clinical outcomes remains unclear. Objective: To examine the association between alterations in emotion processing and regional gray matter volumes in individuals at clinical high risk (CHR) for psychosis, and the association with subsequent clinical outcomes. Design, Setting, and Participants: This naturalistic case-control study with clinical follow-up at 12 months was conducted from July 1, 2010, to August 31, 2016, a..

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University of Melbourne Researchers

Barnaby Nelson Author

Patrick McGorry Author

Christos Pantelis Author

Lucia Valmaggia Author

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Awarded by Institut National de la Santé et de la Recherche Médicale

Funding Acknowledgements

The European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) Project is funded by grant agreement HEALTH-F2-2010-241909 (Project EU-GEI) from the European Community Seventh Framework Programme. Additional financial support was obtained from the Institut National de la Sante et de la Recherche Medicale (recurrent funding and fellowships) and by Fondation Pierre Deniker. The study received grant 08-MNP-007 from the French government Agence Nationale de la Recherche and grant AOM-07-118 (Influence of Cannabis Psychopathological Outcome in At-risk Mental State [ICAAR study]) from the French Health Ministry Programme Hospitalier de Recherche Clinique. The Sainte-Anne Hospital Center promoted the study. Dr Kempton was supported by a Medical Research Council Fellowship grant MR/J008915/1. Dr Pantelis was supported by Australia's National Health and Medical Research Council Senior Principal Research Fellowship (ID: 628386 & 1105825) and by grant R246-2016-3237 from the Lundbeck Foundation. Dr Barrantes-Vidal was supported by the Ministerio de Ciencia, Innovacion e Universidades (PSI2017-87512-C2-1-R), and the Generalitat de Catalunya (2017SGR1612 and ICREA Academia Award). Dr Modinos was supported by a Sir Henry Dale Fellowship #202397/Z/16/Z, jointly funded by The Wellcome Trust and the Royal Society.