Journal article

The Biomolecular Corona in 2D and Reverse: Patterning Metal–Phenolic Networks on Proteins, Lipids, Nucleic Acids, Polysaccharides, and Fingerprints

G Yun, JJ Richardson, M Capelli, Y Hu, QA Besford, ACG Weiss, H Lee, IS Choi, BC Gibson, P Reineck, F Caruso

Advanced Functional Materials | Wiley | Published : 2020

Abstract

The adsorption of biomolecules onto nanomaterials can alter the performance of the nanomaterials in vitro and in vivo. Recent studies have primarily focused on the protein “corona”, formed upon adsorption of proteins onto nanoparticles in biological fluids, which can change the biological fate of the nanoparticles. Conversely, interactions between nanomaterials and other classes of biomolecules namely, lipids, nucleic acids, and polysaccharides have received less attention despite their important roles in biology. A possible reason is the challenge associated with investigating biomolecule interactions with nanomaterials using current technologies. Herein, a protocol is developed for studyin..

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Grants

Awarded by Australian Research Council (ARC)


Funding Acknowledgements

G.Y. and J.J.R. contributed equally to this work. This research was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio‐Nano Science and Technology (Project No. CE140100036), the ARC Centre of Excellence for Nanoscale BioPhotonics (Project No. CE140100003), and an ARC Discovery Project (DP170103331). This work was partly conducted on the SAXS beamline of the Australian Synchrotron, part of ANSTO. This work was performed in part at the Materials Characterization and Fabrication Platform (MCFP) at The University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF). F.C. acknowledges the award of a National Health and Medical Research Council Senior Principal Research Fellowship (GNT1135806). P.R. acknowledges funding through the RMIT Vice Chancellor's Research Fellowship. M.C. acknowledges the support of a Ph.D. scholarship from the ARC Centre of Excellence for Nanoscale BioPhotonics and RMIT University. I.S.C. acknowledges the support of the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (MSIP2012R1A3A2026403).