Journal article

Annexin-A1 deficiency exacerbates pathological remodelling of the mesenteric vasculature in insulin-resistant, but not insulin-deficient, mice

Maria Jelinic, Nicola Kahlberg, Chen Huei Leo, Hooi Hooi Ng, Sarah Rosli, Minh Deo, Mandy Li, Siobhan Finlayson, Jesse Walsh, Laura J Parry, Rebecca H Ritchie, Cheng Xue Qin

British Journal of Pharmacology | Wiley | Published : 2020

Abstract

Background and purpose Arterial stiffness, a characteristic feature of diabetes, increases the risk of cardiovascular complications. Potential mechanisms that promote arterial stiffness in diabetes include oxidative stress, glycation and inflammation. The anti‐inflammatory protein annexin‐A1 has cardioprotective properties, particularly in the context of ischaemia. However, the role of endogenous annexin‐A1 in the vasculature in both normal physiology and pathophysiology remains largely unknown. Hence, this study investigated the role of endogenous annexin‐A1 in diabetes‐induced remodelling of mouse mesenteric vasculature. Experimental approach Insulin‐resistance was induced in male mice (A..

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