Longitudinal Analysis of Group A Streptococcus emm Types and emm Clusters in a High-Prevalence Setting: Relationship between Past and Future Infections.

Patricia Therese Campbell; Steven YC Tong; Nicholas Geard; Mark R Davies; Kate A Worthing; Jake A Lacey; Pierre R Smeesters; Michael R Batzloff; Joseph Kado; Adam WJ Jenney; Jodie Mcvernon; Andrew C Steer

Journal article

Longitudinal Analysis of Group A Streptococcus emm Types and emm Clusters in a High-Prevalence Setting: Relationship between Past and Future Infections.

Patricia Therese Campbell, Steven YC Tong, Nicholas Geard, Mark R Davies, Kate A Worthing, Jake A Lacey, Pierre R Smeesters, Michael R Batzloff, Joseph Kado, Adam WJ Jenney, Jodie Mcvernon, Andrew C Steer

Journal of Infectious Diseases | Oxford University Press (OUP) | Published : 2020

DOI: 10.1093/infdis/jiz615

Abstract

Group A Streptococcus is a pathogen of global importance, but despite the ubiquity of group A Streptococcus infections, the relationship between infection, colonization, and immunity is still not completely understood. The M protein, encoded by the emm gene, is a major virulence factor and vaccine candidate and forms the basis of a number of classification systems. Longitudinal patterns of emm types collected from 457 Fijian schoolchildren over a 10-month period were analyzed. No evidence of tissue tropism was observed, and there was no apparent selective pressure or constraint of emm types. Patterns of emm type acquisition suggest limited, if any, modification of future infection based on i..

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University of Melbourne Researchers

Trish Campbell Author Infectious Diseases

Steven Tong Author Infectious Diseases

Andrew Steer Author Paediatrics Royal Children's Hospital

Jake Lacey Author Infectious Diseases

Mark Davies Author Microbiology and Immunology

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Grants

Awarded by National Institute of Allergy and Infectious Diseases

Awarded by Australian National Health and Medical Research Council (Career Development Fellowship)

Funding Acknowledgements

This work was supported by the National Institute of Allergy and Infectious Diseases (grant U01AI60579) and the Australian National Health and Medical Research Council (Career Development Fellowship GNT1145033 to S. Y. C. T., Principal Research Fellowship GNT1117140 to J. M., and project grants GNT1098319 and GNT1130455).