Journal article
CRISTAL: Protocol for a cluster randomised, crossover, non-inferiority trial of aspirin compared to low molecular weight heparin for venous thromboembolism prophylaxis in hip or knee arthroplasty, a registry nested study
VS Sidhu, SE Graves, R Buchbinder, JM Naylor, NL Pratt, RS De Steiger, BH Chong, IN Ackerman, S Adie, A Harris, A Hansen, M Cripps, M Lorimer, S Webb, O Clavisi, EC Griffith, D Anandan, G O'Donohue, TL Kelly, IA Harris
BMJ Open | BMJ PUBLISHING GROUP | Published : 2019
Abstract
Introduction Venous thromboembolism (VTE) is a serious complication following hip arthroplasty (HA) and knee arthroplasty (KA). This study aims to determine whether aspirin is non-inferior to low molecular weight heparin (LMWH) in preventing symptomatic VTE following HA and KA. Methods and analysis This is a cluster randomised, crossover, non-inferiority, trial nested within the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR). The clusters will consist of Australian hospitals performing at least 250 HA and/or KA procedures per annum. All adult patients undergoing HA or KA will be included. The intervention will be aspirin, orally, 85-150 mg daily. The compara..
View full abstractGrants
Awarded by South Australian Health and Medical Research Institute
Funding Acknowledgements
The study is being funded by a 4-year Medical Research Futures Fund (Australian Federal Government) grant.