Journal article

Cognitive behavioral therapy in adolescents with early-onset psychosis: a randomized controlled pilot study.

Hendrik Müller, Mareike Kommescher, Jörn Güttgemanns, Helen Wessels, Petra Walger, Gerd Lehmkuhl, Kathrin Kuhr, Stefanie Hamacher, Walter Lehmacher, Kerstin Müller, Jutta Herrlich, Georg Wiedemann, Dieter Stösser, Stefan Klingberg, Andreas Bechdolf

Eur Child Adolesc Psychiatry | Published : 2020


Cognitive behavioral therapy for psychosis (CBT) is an effective treatment in adult patients with schizophrenia. However, no randomized controlled and blinded trial in adolescents with early-onset psychosis (EOP) has been conducted. Therefore, the present pilot study explores the acceptance, tolerability, feasibility, and safety of a modified CBT in adolescents with EOP. Twenty-five adolescents with EOP were randomized to either 9 months (20 sessions) of CBT + treatment as usual (TAU) or TAU alone. The primary endpoint was the PANSS-positive subscale (P1-7). Secondary endpoints included psychopathology, global functioning, and quality of life (QoL). Acceptance, tolerability, feasibility, and..

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