Journal article

Plant poisoning leads to alpha-synucleinopathy and neuromelanopathy in kangaroos

Mourad Tayebi, Charles M El-Hage, Pedro Pinczowski, Pam Whiteley, Monique David, Qiao-Xin Li, Shiji Varghese, Meena Mikhael, Umma Habiba, David Harman, Liliana Tatarczuch, Mirjana Bogeski, Ian Birchall, Kirsty Ferguson, Larry Walker, Colin Masters, Brian A Summers

Scientific Reports | NATURE PUBLISHING GROUP | Published : 2019

Abstract

The pathogenesis of synucleinopathies, common neuropathological lesions normally associated with some human neurodegenerative disorders such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy, remains poorly understood. In animals, ingestion of the tryptamine-alkaloid-rich phalaris pastures plants causes a disorder called Phalaris staggers, a neurological syndrome reported in kangaroos. The aim of the study was to characterise the clinical and neuropathological changes associated with spontaneous cases of Phalaris staggers in kangaroos. Gross, histological, ultrastructural and Immunohistochemical studies were performed to demonstrate neuronal accumulation of neurom..

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