Journal article

Preexisting illness, fetal malformation, and seizure control rates in pregnant women with epilepsy

Frank John Emery Vajda, Terence John O'Brien, Janet Elizabeth Graham, Alison Anne Hitchcock, Cecilie Margaret Lander, Mervyn John Eadie

Epilepsy & Behavior | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020


Data from 2182 pregnancies in the Australian Register of antiepileptic drugs in pregnancy that were followed to term, with 1965 followed for another year, were analyzed to ascertain whether preexisting illness influenced i. the hazard of fetal malformations, and ii. seizure control during pregnancy. Fetal malformation occurred in 74 of the 842 pregnancies associated with preexisting illness (8.8%) and in 84 of the 1340 comparator pregnancies (6.27%), Relative Risk (R.R.) = 1.402 (95% Confidence Interval (C.I.) = 1.038, 1.893). Logistic regression showed statistically significant effects of preexisting maternal drug-treated psychiatric illness, untreated psychiatric illness, and use of citalo..

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Funding Acknowledgements

We thank medical and other professional colleagues who referred patients to the APR, and also the APR's Scientific Advisory Board. The Research Ethics Committees of St. Vincent's, Monash Medical Centre, the Royal Melbourne Hospital, and other institutions are thanked for continuing ethics oversight of the APR. Financial support for the Australian Pregnancy Register has been provided by Epilepsy Society of Australia, Royal Melbourne Hospital Neuroscience Foundation, Epilepsy Action Australia, the NHMRC, the pharmaceutical companies Sanofi-Aventis, UCB Pharma, Sci-Gen, Eisai, and Sanofi/Genzyme.