Neuroinflammation in Post-Traumatic Epilepsy: Pathophysiology and Tractable Therapeutic Targets
Rishabh Sharma, Wai Lam Leung, Akram Zamani, Terence J O'Brien, Pablo M Casillas Espinosa, Bridgette D Semple
Brain Sciences | MDPI | Published : 2019
Epilepsy is a common chronic consequence of traumatic brain injury (TBI), contributing to increased morbidity and mortality for survivors. As post-traumatic epilepsy (PTE) is drug-resistant in at least one-third of patients, there is a clear need for novel therapeutic strategies to prevent epilepsy from developing after TBI, or to mitigate its severity. It has long been recognized that seizure activity is associated with a local immune response, characterized by the activation of microglia and astrocytes and the release of a plethora of pro-inflammatory cytokines and chemokines. More recently, increasing evidence also supports a causal role for neuroinflammation in seizure induction and prop..View full abstract
The authors receive funding support from the National Health and Medical Research Council of Australia (B.D.S, T.J.O'B and P.M.C), Australian Government (R.S) and Monash University (B.D.S and T.J.O'B).