Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation
Terry CC Lim Kam Sian, Saranjah Indumathy, Hanim Halim, Anja Greule, Max J Cryle, Paul Bowness, Jamie Rossjohn, Stephanie Gras, Anthony W Purcell, Ralf B Schittenhelm
Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2019
Expression of human leukocyte antigen (HLA)-B27 is strongly associated with predisposition toward ankylosing spondylitis (AS) and other spondyloarthropathies. However, the exact involvement of HLA-B27 in disease initiation and progression remains unclear. The homodimer theory, which proposes that HLA-B27 heavy chains aberrantly form homodimers, is a central hypothesis that attempts to explain the role of HLA-B27 in disease pathogenesis. Here, we examined the ability of the eight most prevalent HLA-B27 allotypes (HLA-B*27:02 to HLA-B*27:09) to form homodimers. We observed that HLA-B*27:03, a disease-associated HLA-B27 subtype, showed a significantly reduced ability to form homodimers compared..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
This work was supported by the Australian Research Council (ARC) and the National Health and Medical Research Council (NHMRC) Project 1085017. The authors declare that they have no conflicts of interest with the contents of this article.