Journal article

Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation

Terry CC Lim Kam Sian, Saranjah Indumathy, Hanim Halim, Anja Greule, Max J Cryle, Paul Bowness, Jamie Rossjohn, Stephanie Gras, Anthony W Purcell, Ralf B Schittenhelm

Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2019

Abstract

Expression of human leukocyte antigen (HLA)-B27 is strongly associated with predisposition toward ankylosing spondylitis (AS) and other spondyloarthropathies. However, the exact involvement of HLA-B27 in disease initiation and progression remains unclear. The homodimer theory, which proposes that HLA-B27 heavy chains aberrantly form homodimers, is a central hypothesis that attempts to explain the role of HLA-B27 in disease pathogenesis. Here, we examined the ability of the eight most prevalent HLA-B27 allotypes (HLA-B*27:02 to HLA-B*27:09) to form homodimers. We observed that HLA-B*27:03, a disease-associated HLA-B27 subtype, showed a significantly reduced ability to form homodimers compared..

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University of Melbourne Researchers